The availability of human genome sequence has transformed biomedical research over the
past decade. However, an equivalent map for the human proteome with direct …

Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder
caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect …

Cells with distinct phenotypes including stem-cell-like properties have been proposed to exist
in normal human mammary epithelium and breast carcinomas, but their detailed molecular …

Sequence variation in human genes is largely confined to single-nucleotide polymorphisms
(SNPs) and is valuable in tests of association with common diseases and pharmacogenetic …

Purpose Contrary to the extensive data accumulated regarding pancreatic carcinogenesis,
the clinical and molecular features characteristic of advanced stage (stage III and IV) disease …

Recent controversies surrounding prostate cancer overtreatment emphasize the critical need
to delineate the molecular features associated with progression to lethal metastatic disease…

Inflammatory diseases of the aorta include routine atherosclerosis, aortitis, periaortitis, and
atherosclerosis with excessive inflammatory responses, such as inflammatory atherosclerotic …

The Association for European Cardiovascular Pathology and the Society for Cardiovascular
Pathology have produced this position paper concerning the current role of endomyocardial …

Background The diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) can
be challenging because the clinical presentation is highly variable and genetic penetrance is …

The COVID-19 pandemic, the result of severe acute respiratory syndrome (SARS)-CoV-2, is
a major cause of worldwide mortality with a significant cardiovascular component. While a …