The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by
PTPN11, is involved in signal transduction downstream of multiple growth factor, cytokine …

Attractive chlorine: Noncovalent interactions between chlorine or bromine atoms and aromatic
rings in proteins open up a new method for the manipulation of molecular recognition. …

Structure−activity relationships within a series of highly potent 2-carboxyindole-based factor
Xa inhibitors incorporating a neutral P1 ligand are described with particular emphasis on the …

Herein we report the development of a turn‐on lanthanide luminescent probe for time‐gated
detection of nitroreductases (NTRs) in live bacteria. The probe is activated through NTR‐…

… Marc Nazaré*, Claudia Schneider, Andreas Lindenschmidt, David William Will *Aventis
Pharma Deutschland GmbH, Medicinal Chemistry, DI&A Chemistry, Building G878, 65926 …

Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of
increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, …

In drug development, late stage toxicity issues of a compound are the main cause of failure
in clinical trials. In silico methods are therefore of high importance to guide the early design …

Jumonji domain-containing lysine demethylase (KDM) enzymes are encoded by genes of
the KDM superfamily. Activities of the KDM4 subfamily promote aggressive phenotypes …

Pharmacological modulation of cannabinoid type 2 receptor (CB 2 R) holds promise for the
treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, …

Despite its essential role in the (patho)physiology of several diseases, CB2R tissue
expression profiles and signaling mechanisms are not yet fully understood. We report the …