INTRODUCTION Protein homeostasis in the endoplasmic reticulum (ER) is maintained by a
quality control system. When a newly synthesized ER protein misfolds, it is ultimately …

INTRODUCTION The eukaryotic nucleus protects the genome and is enclosed by the two
membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear …

The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper
for the transport between the nucleus and cytosol 1 . The central channel of the NPC is filled …

Living cells constantly remodel the shape of their lipid membranes. In the endoplasmic
reticulum (ER), the reticulon homology domain (RHD) of the reticulophagy regulator 1 (RETR1/…

We develop a detailed description of protein translational and rotational diffusion in concentrated
solution on the basis of all-atom molecular dynamics simulations in explicit solvent. Our …

The cell membrane and many organellar membranes are asymmetric and highly curved. In
experiments, it is challenging to reconstitute and characterize membranes that differ in the …

Molecular dynamics (MD) simulations have become ubiquitous in all areas of life sciences.
The size and model complexity of MD simulations are rapidly growing along with increasing …

Microtubules are a ubiquitous eukaryotic cytoskeletal element typically consisting of 13
protofilaments arranged in a hollow cylinder. This arrangement is considered the canonical form …

Drug delivery mitigates toxic side effects and poor pharmacokinetics of life-saving therapeutics
and enhances treatment efficacy. However, direct cytoplasmic delivery of drugs and …

Nuclear pore complexes (NPCs) mediate nucleocytoplasmic transport. Their intricate 120 MDa
architecture remains incompletely understood. Here, we report a near-complete structural …