The total number of glomeruli is a fundamental parameter of kidney function but very difficult
to determine using standard methodology. Here, we counted all individual glomeruli in …

Affinity maturation of B cells in germinal centers (GCs) is a process of evolution, involving
random mutation of immunoglobulin genes followed by natural selection by T cells. Only B …

Life-threatening systemic infections often occur due to the translocation of pathogens across
the gut barrier and into the bloodstream. While the microbial and host mechanisms …

Germinal centers (GCs) are specialized microenvironments where antigen-activated B cells
undergo proliferation, immunoglobulin (Ig) class switch recombination, somatic …

Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality
control. Impairment thereof was proposed to be causative to neurodegenerative diseases, …

Alterations of the microbial composition in the gut and the concomitant dysregulation of the
mucosal immune response are associated with the pathogenesis of opportunistic infections, …

The majority of today's antimicrobial therapeutics is derived from secondary metabolites
produced by Actinobacteria. While it is generally assumed that less than 1% of Actinobacteria …

The decision whether endosomes enter the degradative or recycling pathway in mammalian
cells is of fundamental importance for pathogen killing, and its malfunctioning has …

Personalized medicine is a modern healthcare approach where information on each person's
unique clinical constitution is exploited to realize early disease intervention based on …

Automated microscopy has given researchers access to great amounts of live cell imaging
data from in vitro and in vivo experiments. Much focus has been put on extracting cell tracks …