In clinical exome and genome sequencing, there is a potential for the recognition and
reporting of incidental or secondary findings unrelated to the indication for ordering the …

Despite extraordinary efforts to profile cancer genomes, interpreting the vast amount of
genomic data in the light of cancer evolution remains challenging. Here we demonstrate that …

Subclonal architectures are prevalent across cancer types. However, the temporal evolutionary
dynamics that produce tumor subclones remain unknown. Here we measure clone …

Although the potential for genomics to contribute to clinical care has long been anticipated,
the pace of defining the risks and benefits of incorporating genomic findings into medical …

The Electronic Medical Records and Genomics Network is a National Human Genome
Research Institute–funded consortium engaged in the development of methods and best …

CHARGE association is a nonrandom pattern of congenital anomalies that occurs together
more frequently than one would expect on the basis of chance. This common multiple …

Introduction Reporting and sharing pharmacogenetic test results across clinical laboratories
and electronic health records is a crucial step toward the implementation of clinical …

As more research studies incorporate next-generation sequencing (including whole-genome
or whole-exome sequencing), investigators and institutional review boards face difficult …

As scientific evidence of the severity of climate change increases, there are indications that
this represents a significant psychological burden in the form of climate anxiety on the public. …

High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability 1
, 2 , 3 – 4 patterned by distinct mutational processes 5 , 6 , tumour heterogeneity 7 , 8 – 9 …