Whole organism–based small-molecule screens have proven powerful in identifying novel
therapeutic chemicals, yet this approach has not been exploited to identify new cognitive …

Habituation represents a fundamental form of learning, yet the underlying molecular genetic
mechanisms are not well defined. Here we report on a genome-wide genetic screen, …

Class 3 semaphorins are known to repel and/or sometimes attract axons; however, their role
in guiding developing axons in the CNS in vivo is still essentially unknown. We investigated …

Animals continuously integrate sensory information and select contextually appropriate
responses. Here, we show that zebrafish larvae select a behavioral response to acoustic stimuli …

In vertebrates, the peripheral nervous system has retained its regenerative capacity, enabling
severed axons to reconnect with their original synaptic targets. While it is well documented …

Neurofibromatosis type 1 (NF1) is a common, dominantly inherited genetic disorder that
results from mutations in the neurofibromin 1 (NF1) gene. Affected individuals demonstrate …

Deciphering the genetic code that determines how the vertebrate nervous system assembles
into neural circuits that ultimately control behavior is a fascinating and challenging question …

Cell–cell recognition guides the assembly of the vertebrate brain during development. δ-Protocadherins
comprise a family of neural adhesion molecules that are differentially expressed …

Neurofibromatosis type 1 (NF1) is a common autosomal-dominant disorder associated with
attention deficits and learning disabilities. The primary known function of neurofibromin, …

The actin-binding protein plastin 3 (PLS3) has been identified as a modifier of the human
motoneuron disease spinal muscular atrophy (SMA). SMA is caused by decreased levels of the …