Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on
insights gleaned from almost a quarter century of research, it is obvious that deregulation of …

… Marc de la Roche … How to cite this article: de la Roche, M. et al. An intrinsically labile α-helix
abutting the BCL9-binding site of β-catenin is required for its inhibition by … Marc de la Roche …

Th17 cells are key drivers of autoimmune disease. However, the signaling pathways
regulating Th17 polarization are poorly understood. Hedgehog signaling regulates cell fate …

Dictyostelium expresses 12 different myosins, including seven single-headed myosins I and
one conventional two-headed myosin II. In this review we focus on the signaling pathways …

Background Most cases of colorectal cancer are initiated by hyperactivation of the Wnt/β-catenin
pathway due to mutations in the APC tumour suppressor, or in β-catenin itself. A …

Dictyostelium myosin II is a conventional, two-headed myosin that consists of two copies each
of a myosin heavy chain (MHC), an essential light chain (ELC) and a regulatory light chain …

Hyperactive β-catenin drives colorectal cancer, yet inhibiting its activity remains a formidable
challenge. Interest is mounting in tankyrase inhibitors (TNKSi), which destabilize β-catenin …

We report a double-click macrocyclization approach for the design of constrained peptide
inhibitors having non-helical or extended conformations. Our targets are the tankyrase proteins …

The media formulations necessary for deriving and sustaining organoids from epithelial
tissues such as prostate, colon, gastric, liver, pancreas, and others have been established. …

APC mutations cause activation of Wnt/β-catenin signaling, which invariably leads to colorectal
cancer. Similarly, overexpressed Dvl proteins are potent activators of β-catenin signaling. …