[HTML][HTML] Efficacy and safety of a recombinant plant-based adjuvanted Covid-19 vaccine

…, F Roman, J Namba, MA D'Aoust… - New England journal …, 2022 - Mass Medical Soc
Background Coronavirus-like particles (CoVLP) that are produced in plants and display the
prefusion spike glycoprotein of the original strain of severe acute respiratory syndrome …

[HTML][HTML] Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19

…, I Boulay, PY Charbonneau, M Couture, MA D'Aoust… - Nature medicine, 2021 - nature.com
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being
deployed, but the global need greatly exceeds the supply, and different formulations might …

The production of hemagglutinin‐based virus‐like particles in plants: a rapid, efficient and safe response to pandemic influenza

MA D'Aoust, MMJ Couture, N Charland… - Plant biotechnology …, 2010 - Wiley Online Library
During the last decade, the spectre of an influenza pandemic of avian origin has led to a
revision of national and global pandemic preparedness plans and has stressed the need for …

Influenza virus‐like particles produced by transient expression in Nicotiana benthamiana induce a protective immune response against a lethal viral challenge in …

MA D'Aoust, PO Lavoie, MMJ Couture… - Plant biotechnology …, 2008 - Wiley Online Library
A strain‐specific vaccine represents the best possible response to the threat of an influenza
pandemic. Rapid delivery of such a vaccine to the world's population before the peak of the …

Antisense inhibition of tomato fruit sucrose synthase decreases fruit setting and the sucrose unloading capacity of young fruit

MA D'Aoust, S Yelle, B Nguyen-Quoc - The Plant Cell, 1999 - academic.oup.com
The role of sucrose synthase (SuSy) in tomato fruit was studied in transgenic tomato (Lycopersicon
esculentum) plants expressing an antisense fragment of fruit-specific SuSy RNA (…

Transient co‐expression for fast and high‐yield production of antibodies with human‐like N‐glycans in plants

…, L Faye, P Lerouge, MA D'Aoust… - Plant biotechnology …, 2009 - Wiley Online Library
Plant‐based transient expression is potentially the most rapid and cost‐efficient system for
the production of recombinant pharmaceutical proteins, but safety concerns associated with …

Plant-produced biopharmaceuticals: a case of technical developments driving clinical deployment

GP Lomonossoff, MA D'Aoust - Science, 2016 - science.org
The ability to express heterologous proteins in plants has led to the concept of using plants
as “bioreactors” or “biofactories” for the production of pharmaceutical proteins. Although …

Multiplexed, targeted gene editing in Nicotiana benthamiana for glyco‐engineering and monoclonal antibody production

…, L Mathis, DF Voytas, MA D'Aoust… - Plant biotechnology …, 2016 - Wiley Online Library
Biopharmaceutical glycoproteins produced in plants carry N‐glycans with plant‐specific
residues core α(1,3)‐fucose and β(1,2)‐xylose, which can significantly impact the activity, …

[HTML][HTML] Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine …

…, S Trépanier, N Charland, MA D'Aoust… - Cellular & molecular …, 2022 - nature.com
Although antivirals are important tools to control severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, effective vaccines are essential to control the current …

Expression of multiple proteins using full‐length and deleted versions of cowpea mosaic virus RNA‐2

F Sainsbury, PO Lavoie, MA D'Aoust… - Plant Biotechnology …, 2008 - Wiley Online Library
The use of multiple copies of vectors based on either full‐length or deleted versions of cowpea
mosaic virus RNA‐2 for the production of heteromeric proteins in plants was investigated. …