Dense connectomic reconstruction in layer 4 of the somatosensory cortex

A Motta, M Berning, KM Boergens, B Staffler, M Beining… - Science, 2019 - science.org
INTRODUCTION The brain of mammals consists of an enormously dense network of neuronal
wires: the axons and dendrites of nerve cells. Their packing density is so high that light-…

Structural homo-and heterosynaptic plasticity in mature and adult newborn rat hippocampal granule cells

T Jungenitz, M Beining, T Radic… - Proceedings of the …, 2018 - National Acad Sciences
Adult newborn hippocampal granule cells (abGCs) contribute to spatial learning and
memory. abGCs are thought to play a specific role in pattern separation, distinct from …

T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells

M Beining, LA Mongiat, SW Schwarzacher, H Cuntz… - elife, 2017 - elifesciences.org
10.7554/eLife.26517.001 Compartmental models are the theoretical tool of choice for
understanding single neuron computations. However, many models are incomplete, built ad hoc …

Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cells

M Beining, T Jungenitz, T Radic, T Deller… - Brain Structure and …, 2017 - Springer
Adult-born dentate granule cells (abGCs) exhibit a critical developmental phase during
function integration. The time window of this phase is debated and whether abGCs become …

[PDF][PDF] A general principle of dendritic constancy: A neuron's size-and shape-invariant excitability

H Cuntz, AD Bird, M Mittag, M Beining, M Schneider… - Neuron, 2021 - cell.com
Reducing neuronal size results in less membrane and therefore lower input conductance.
Smaller neurons are thus more excitable, as seen in their responses to somatic current …

[HTML][HTML] Time-lapse imaging reveals highly dynamic structural maturation of postnatally born dentate granule cells in organotypic entorhino-hippocampal slice cultures

T Radic, T Jungenitz, M Singer, M Beining, H Cuntz… - Scientific reports, 2017 - nature.com
Neurogenesis of hippocampal granule cells (GCs) persists throughout mammalian life and
is important for learning and memory. How newborn GCs differentiate and mature into an …

[HTML][HTML] Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging

…, U Hennrich, K Nokihara, M Beining… - … journal of medical …, 2012 - ncbi.nlm.nih.gov
Progress in genomics and proteomics attended to the door for better understanding the
recent rapid expanding complex research field of metabolomics. This trend in biomedical …

[HTML][HTML] Differential structural development of adult-born septal hippocampal granule cells in the Thy1-GFP mouse, nuclear size as a new index of maturation

T Radic, O Al-Qaisi, T Jungenitz, M Beining… - PLoS …, 2015 - journals.plos.org
Adult neurogenesis is frequently studied in the mouse hippocampus. We examined the
morphological development of adult-born, immature granule cells in the suprapyramidal blade of …

[HTML][HTML] BioShuttle mobility in living cells studied with high-resolution FCS & CLSM methodologies

K Braun, M Beining, M Wiessler… - … journal of medical …, 2012 - ncbi.nlm.nih.gov
With the increase in molecular diagnostics and patient-specific therapeutic approaches, the
delivery and targeting of imaging molecules and pharmacologically active agents gain …

Dense connectomic reconstruction in layer 4 of the somatosensory cortex

A Motta, M Berning, KM Boergens, B Staffler, M Beining… - bioRxiv, 2018 - biorxiv.org
The dense circuit structure of the mammalian cerebral cortex is still unknown. With
developments in 3-dimensional (3D) electron microscopy, the imaging of sizeable volumes of …