Voltage-gated sodium channels are critical for the generation and propagation of electrical
signals in most excitable cells. Activation of Na + channels initiates an action potential, and …

Voltage-dependent Na + channels are crucial for electrical signalling in excitable cells.
Membrane depolarization initiates asynchronous movements in four non-identical voltage-…

Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that target
GABA A receptors (GABA A Rs) to tune inhibitory synaptic signaling throughout the central …

10.7554/eLife.20797.001 Although molecular recognition is crucial for cellular signaling,
mechanistic studies have relied primarily on ensemble measures that average over and …

Single‐molecule fluorescence microscopy is a powerful tool for revealing chemical dynamics
and molecular association mechanisms, but has been limited to low concentrations of …

Otopetrin proteins (OTOPs) form proton-selective ion channels that are expressed in diverse
cell types where they mediate detection of acids or regulation of pH. In vertebrates there are …

Single-molecule approaches provide enormous insight into the dynamics of biomolecules,
but adequately sampling distributions of states and events often requires extensive sampling. …

Members of the voltage-gated ion channel superfamily (VGIC) regulate ion flux and generate
electrical signals in excitable cells by opening and closing pore gates. The location of the …

… Author contributions: RA Pearce conceived the study, MP Goldschen-Ohm and RA Pearce …
Goldschen-Ohm and RA Pearce developed the simulation software, and MP Goldschen-Ohm …

The GABA A receptor mutation γ 2 R43Q causes absence epilepsy in humans. Homology
modeling suggests that γ 2 Arg43, γ 2 Glu178, and β 2 Arg117 participate in a salt-bridge …