To identify approaches to target DNA repair vulnerabilities in cancer, we discovered
nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase …

Posttranscriptional gene silencing in Caenorhabditis elegans results from exposure to
double-stranded RNA (dsRNA), a phenomenon designated as RNA interference (RNAi), or from …

Cells are protected from toxic DNA double-stranded breaks (DSBs) by a number of DNA repair
mechanisms, including some that are intrinsically error prone, thus resulting in mutations. …

RNA interference (RNAi) is a broadly used reverse genetics method in C. elegans [1].
Unfortunately, RNAi does not inhibit all genes [2, 3]. We show that loss of function of a putative …

The pathway of RNA interference starts when Dicer cuts dsRNA into small interfering RNAs (siRNAs)
that subsequently target homologous mRNAs for destruction. microRNA …

▪ Abstract Although initially recognized as a handy tool to reduce gene expression, RNA
silencing, triggered by double-stranded RNA molecules, is now recognized as a mechanism for …

Small RNA molecules participate in a variety of activities in the cell: in a process known as
RNA interference (RNAi), double-stranded RNA triggers the degradation of messenger RNA …

Recent genetical genomics studies have provided intimate views on gene regulatory networks.
Gene expression variations between genetically different individuals have been mapped …

CRISPR-Cas9 genome editing has potential to cure diseases without current treatments, but
therapies must be safe. Here we show that CRISPR-Cas9 editing can introduce unintended …

Genomes contain many sequences that are intrinsically difficult to replicate. Tracts of tandem
guanines, for instance, have the potential to adopt stable G-quadruplex structures, which …