Elevated resting heart rate is associated with greater risk of cardiovascular disease and
mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 …

Evidence for a major role of genetic factors in the determination of body mass index (BMI)
comes from studies of related individuals. Despite consistent evidence for a heritable …

PURPOSE: Physical activity unquestionably maintains and improves health; however, physical
activity levels globally are low and not rising despite all the resources devoted to this goal…

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Polymorphisms rs6232 and rs6234/rs6235 in PCSK1 have been associated with extreme
obesity [eg body mass index (BMI) ≥ 40 kg/m 2 ], but their contribution to common obesity (…

Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood 1 . Previous genome-…

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …

CRISPR-Cas9 genome editing has potential to cure diseases without current treatments, but
therapies must be safe. Here we show that CRISPR-Cas9 editing can introduce unintended …

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity.
To identify adiposity loci whose effects are modified by PA, we performed genome-wide …

Background Cross-sectional studies have shown that objectively measured physical activity
is associated with childhood adiposity, and a strong inverse dose–response association …