In this study, newly identified small molecules were examined for efficacy against ‘Candidatus
Liberibacter asiaticus’ in commercial groves of sweet orange (Citrus sinensis) and white …

Trypanosoma cruzi, the etiological agent of Chagas' disease, presents nutritional
requirements for several metabolites. It requires heme for the biosynthesis of several heme-proteins …

Acetylation signaling pathways in trypanosomatids, a group of early branching organisms,
are poorly understood due to highly divergent protein sequences. To overcome this challenge…

Heme is an essential cofactor for many biological processes in aerobic organisms, which
can synthesize it de novo through a conserved pathway. Trypanosoma cruzi, the etiological …

Trypanosoma cruzi, the causative agent of Chagas disease, presents a complex life cycle
and adapts its metabolism to nutrients’ availability. Although T. cruzi is an aerobic organism, it …

Liberibacter asiaticus is the prevalent causative pathogen of Huanglongbing or citrus
greening disease, which has resulted in a devastating crisis in the citrus industry. A thorough …

In Liberibacter asiaticus, PrbP is a transcriptional regulatory protein involved in survival and
persistence during host infection. Tolfenamic acid was previously found to inhibit …

‘Candidatus Liberibacter asiaticus’ is known as the most pathogenic organism associated
with citrus greening disease. Since its publicized emergence in Florida in 2005, ‘Ca. L. …

Trypanosoma cruzi (Chagas disease) depends on acquiring nutrients and cofactors, like
copper (Cu), from its hosts. Cu is essential for aerobic organisms, but it can also be toxic, so its …

Heme is an essential cofactor for many biological processes in aerobic organisms. Most of
them can synthesize it de novo via a conserved pathway. Trypanosoma cruzi, the etiological …