Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation (TET)2
gene have been described in various human myeloid malignancies. We report that …

The mechanotransducer channels of auditory hair cells are gated by tip-links, oblique
filaments that interconnect the stereocilia of the hair bundle. Tip-links stretch from the tips of …

While the physiological benefits of the fibroblast growth factor 21 (FGF21) hepatokine are
documented in response to fasting, little information is available on Fgf21 regulation in a …

Background: Senescent cells (SCs) are involved in proliferative disorders, but their role in
pulmonary hypertension remains undefined. We investigated SCs in patients with pulmonary …

Three genes are known to be essential for gamete adhesion/fusion (Cd9, Izumo1 and Juno).
Here, we confirmed that Spaca6 null males are infertile and showed that their sperm …

The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform
content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping …

Gain-of-function mutations in with no lysine (K) 1 (WNK1) and WNK4 genes are responsible
for familial hyperkalemic hypertension (FHHt), a rare, inherited disorder characterized by …

Objective Systemic sclerosis (SSc) is a debilitating autoimmune disease characterized by
severe lung outcomes resulting in reduced life expectancy. Fra‐2–transgenic mice offer the …

In humans, structural or functional defects of the sperm flagellum induce asthenozoospermia,
which accounts for the main sperm defect encountered in infertile men. Herein we focused …

Transforming growth factor-β (TGFβ) signaling is initiated by the type I, II TGFβ receptor (TβRI/TβRII)
complex. Here we report the formation of an alternative complex between TβRI and …