Cyclic paroxysm and high fever are hallmarks of malaria and are associated with high
levels of pyrogenic cytokines, including IL-1β. In this report, we describe a signature for the …

Antiviral CD8 + T cell responses are characterized by an initial activation/priming of T
lymphocytes followed by a massive proliferation, subset differentiation, population contraction and …

Lymphatic transport of molecules and migration of myeloid cells to lymph nodes (LNs)
continuously inform lymphocytes on changes in drained tissues. Here, using LN transplantation, …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or asymptomatic
COVID-19 in most cases, but some patients develop an excessive inflammatory process …

Charcot–Leyden crystals (CLCs) are Galectin-10 protein crystals that can form after eosinophils
degranulate. CLCs can appear and persist in tissues from patients with eosinophilic …

Excessive release of proinflammatory cytokines by innate immune cells is an important
component of the pathogenic basis of malaria. Proinflammatory cytokines are a direct output of …

Dendritic cells have an important role in immune surveillance. After being exposed to microbial
components, they migrate to secondary lymphoid organs and activate T lymphocytes. …

Earlier studies indicate that either the canonical or non-canonical pathways of inflammasome
activation have a limited role on malaria pathogenesis. Here, we report that caspase-8 is a …

High levels of circulating immunocomplexes (ICs) are found in patients with either infectious
or sterile inflammation. We report that patients with either Plasmodium falciparum or …

Recombinant influenza viruses are promising viral platforms to be used as antigen delivery
vectors. To this aim, one of the most promising approaches consists of generating …