Alterations in the composition of the intestinal microbiota have been correlated with aging and
measures of frailty in the elderly. However, the relationships between microbial dynamics, …

Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …

10.7554/eLife.06205.001 Methylation of cytosines (5 me C) is a widespread heritable DNA
modification. During mammalian development, two global demethylation events are followed …

10.7554/eLife.29330.001 The heart switches its energy substrate from glucose to fatty acids
at birth, and maternal hyperglycemia is associated with congenital heart disease. However, …

Background Improvement in the performance of eukaryotic microalgae for biofuel and
bioproduct production is largely dependent on characterization of metabolic mechanisms within …

Maternal nutrient restriction causes the development of adult onset chronic diseases in the
intrauterine growth restricted (IUGR) fetus. Investigations in mice have shown that either …

Heritable epigenetic factors can contribute to complex disease etiology. Here we examine
the contribution of DNA methylation to complex traits that are precursors to heart disease, …

Extrapulmonary manifestations of COVID-19 are associated with a much higher mortality
rate than pulmonary manifestations. However, little is known about the pathogenesis of …

The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk
factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles …

Nutrition plays a significant role in the increasing prevalence of metabolic and brain disorders.
Here we employ systems nutrigenomics to scrutinize the genomic bases of nutrient–host …