Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and
is now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade …

Herpes simplex virus 1 (HSV-1) is a neurotropic pathogen that can infect many types of cells
and establishes latent infections in the neurons of sensory ganglia. In some cases, the virus …

Tauopathies are a group of neurodegenerative diseases characterized by the alteration/aggregation
of TAU protein, for which there is still no effective treatment. Therefore, new …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a pleiotropic transcription factor that has
neuroprotective and anti-inflammatory effects, regulating more than 250 genes. As NRF2, …

Microglial cells are essential mediators of neuroinflammatory processes involved in several
pathologies. Moreover, the chemokine fractalkine (CX3CL1) is essential in the crosstalk …

Glioblastoma (GBM) is the most frequent and aggressive primary tumor type in the central
nervous system in adults. Resistance to chemotherapy remains one of the major obstacles in …

Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and
is now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade …

Preclinical studies of mental illnesses such as schizophrenia do not have models that
resemble or mimic with sufficient/satisfactory validity the complexity of complex psychiatric …

[Results]: In this study we show that CX3CL1 treatment induced NF-ƘB-p65 and pro-inflammatory
cytokines expression. On the other hand, CX3CR1-deficient primary microglia cells …

[Results] We have seen an increase in CB2 expression in hippocampal neurons of 12 month-old
transgenic mice overexpressing hTAUP301S protein. This alteration is an early event …