Patterning of the dorsal-ventral axis in the early Drosophila embryo depends on the nuclear
distribution of the Dorsal transcription factor. Using live two-photon light-sheet microscopy, …

Morphogens are classically defined as molecules that control patterning by acting at a
distance to regulate gene expression in a concentration-dependent manner. In the Drosophila …

Few mechanistic ideas from the pre-molecular era of biology have had as enduring an
impact as the morphogen concept. In the classical view, cells in developing embryos obtain …

Scaling between specific organs and overall body size has long fascinated biologists, being
a primary mechanism by which organ shapes evolve. Yet, the genetic mechanisms that …

Understanding the complex interaction between genotype and phenotype is a major challenge
of Evolutionary Developmental Biology. One important facet of this complex interaction …

How natural variation in embryo size affects patterning of the Drosophila embryo dorsal–ventral
(DV) axis is not known. Here we examined quantitatively the relationship between …

In developing tissues, cell polarization and proliferation are regulated by morphogens and
signaling pathways. Cells throughout the Drosophila wing primordium typically show …

Phenomics requires quantification of large volumes of image data, necessitating high
throughput image processing approaches. Existing image processing pipelines for Drosophila …

Organs mainly attain their size by cell growth and proliferation, but sometimes also grow
through recruitment of undifferentiated cells. Here we investigate the participation of cell …

Cell recruitment is a process by which a differentiated cell induces neighboring cells to adopt
its same cell fate. In Drosophila, cells expressing the protein encoded by the wing selector …