The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2.
Here we analyze, at the single cell level, plasmablasts egressed into the blood to study …

Background The extend of lung disease remains the most important prognostic factor for
survival in patients with cystic fibrosis (CF), and lack of adherence is the main reason for …

T lymphocytes accumulate in inflamed tissues of patients with chronic inflammatory diseases
(CIDs) and express pro‐inflammatory cytokines upon re‐stimulation in vitro. Further, a …

Here we have analyzed the dynamics of the adaptive immune response triggered by SARS-CoV-2
in severely affected COVID-19 patients, as reflected by activated B cells egressing …

Rationale Multiple-breath washout (MBW)-derived lung clearance index (LCI) detects lung
disease in children with cystic fibrosis (CF). Correction of a cross-talk error in the software of …

Introduction/Abstract T lymphocytes accumulate in inflamed tissues of patients with chronic
inflammatory diseases (CIDs) and express pro-inflammatory cytokines upon re-stimulation in …

Changes in the airway microbiome may be important in the pathophysiology of chronic lung
disease in patients with cystic fibrosis. However, little is known about the microbiome in …

This paper introduces quantile regression methods for the analysis of time-seriescross-section
data. Quantile regression offers a robust, and therefore efficient alternative to least …

Background The next-generation cystic fibrosis transmembrane conductance regulator (CFTR)
corrector VX-659, in triple combination with tezacaftor and ivacaftor (VX-659–tezacaftor–…

MARCUS ALEXANDER he survival of Russia’s hybrid postcommunist regime, first under
President Boris Yeltsin and then under President Vladimir Putin, poses difficult challenges for …