User profiles for Marcus Conrad

Marcus Conrad

Helmholtz Zentrum München
Verified email at helmholtz-muenchen.de
Cited by 42861

Ferroptosis: mechanisms, biology and role in disease

X Jiang, BR Stockwell, M Conrad - Nature reviews Molecular cell …, 2021 - nature.com
The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …

[HTML][HTML] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

…, A Ciechanover, GM Cohen, M Conrad… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …

FSP1 is a glutathione-independent ferroptosis suppressor

…, GM Popowicz, DA Pratt, JPF Angeli, M Conrad - Nature, 2019 - nature.com
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to
phospholipids 1 , 2 . To date, ferroptosis has been thought to be controlled only by the …

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

…, JA Schick, VE Kagan, JPF Angeli, M Conrad - Nature chemical …, 2017 - nature.com
Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4).
At present, mechanisms that could predict sensitivity and/or resistance and that may …

[PDF][PDF] Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

BR Stockwell, JPF Angeli, H Bayir, AI Bush, M Conrad… - Cell, 2017 - cell.com
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation
of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis …

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

…, BR Stockwell, YY Tyurina, M Conrad… - Nature chemical …, 2017 - nature.com
Enigmatic lipid peroxidation products have been claimed as the proximate executioners of
ferroptosis—a specialized death program triggered by insufficiency of glutathione peroxidase …

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

…, VB O'Donnell, VE Kagan, JA Schick, M Conrad - Nature cell …, 2014 - nature.com
Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour
types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-…

[HTML][HTML] Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent-and AIF-mediated cell death

…, W Wurst, GW Bornkamm, U Schweizer, M Conrad - Cell metabolism, 2008 - cell.com
Oxidative stress in conjunction with glutathione depletion has been linked with various acute
and chronic degenerative disorders, yet the molecular mechanisms have remained unclear…

[HTML][HTML] A non-canonical vitamin K cycle is a potent ferroptosis suppressor

…, T Abe, M Fedorova, B Proneth, DA Pratt, M Conrad - Nature, 2022 - nature.com
Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation
1 , has a key role in organ injury, degenerative disease and vulnerability of therapy-resistant …

[PDF][PDF] Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis

…, U Schweizer, H Zischka, JPF Angeli, M Conrad - Cell, 2018 - cell.com
Selenoproteins are rare proteins among all kingdoms of life containing the 21 st amino acid,
selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of …