… Marcus Fändrich … Marcus Fändrich, Matthew A. Fletcher & Christopher M. Dobson …
Marcus Fändrich …

The presence of β‐sheets in the core of amyloid fibrils raised questions as to whether or not
β‐sheet‐containing proteins, such as transthyretin, are predisposed to form such fibrils. …

Amyloid fibrils and prions are proteinaceous aggregates that are based on a unique form of
polypeptide configuration, termed cross-β structure. Using a group of chemically distinct …

Amyloid diseases are global epidemics with profound health, social and economic implications
and yet remain without a cure. This dire situation calls for research into the origin and …

The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer’s disease and
cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue …

Several lines of evidence indicate that prefibrillar assemblies of amyloid-β (Aβ) polypeptides,
such as soluble oligomers or protofibrils, rather than mature, end-stage amyloid fibrils …

Deposits of amyloid fibrils characterize a diverse group of human diseases that includes
Alzheimer’s disease, Creutzfeldt-Jakob disease and type II diabetes. Amyloid fibrils formed from …

The formation of amyloid fibrils is a common biochemical characteristic that occurs in Alzheimer's
disease and several other amyloidoses. The unifying structural feature of amyloid fibrils …

Oligomeric intermediates are non-fibrillar polypeptide assemblies that occur during amyloid
fibril formation and that are thought to underlie the aetiology of amyloid diseases, such as …

Amyloid fibrils characterize a diverse group of human diseases that includes Alzheimer's
disease, Creutzfeldt-Jakob and type II diabetes. Alzheimer's amyloid fibrils consist of amyloid-β (…