Recent reports of increased tolerance to artemisinin derivatives—the most recently adopted
class of antimalarials—have prompted a need for new treatments. The spirotetrahydro-β-…

▪ Abstract The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in
protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between …

This report presents a synthesis and integration of the findings of the four MA Working Groups
(Condition and Trends, Scenarios, Responses, and Sub-global Assessments). It does not, …

In 2002, the National Institutes of Health sponsored a meeting concerning methodological
challenges of research in psychosocial interventions in Autism Spectrum Disorders. This …

We have characterized the mechanisms of cargo selection into ER-derived vesicles by the
COPII subunit Sec24p. We identified a site on Sec24p that recognizes the v-SNARE Bet1p …

Secretory proteins traffic from the ER to the Golgi via COPII-coated transport vesicles. The
five core COPII proteins (Sar1p, Sec23/24p, and Sec13/31p) act in concert to capture cargo …

The children complied with most requests. Some of our teaching goals were limited by
technology or space while others were limited by the difficulty of presenting a task to the children …

Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways
essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH …

There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and
novel modes of action, to widen the scope of treatment and to overcome emerging drug …

Background The pharmacological effects of infusion of human brain natriuretic peptide (hBNP)
in patients with severe congestive heart failure have not been characterized previously. …