Background The choline‐derived metabolite trimethylamine N‐oxide ( TMAO ) has been
demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk…

Skeletal muscle plays important roles in whole-body glucose and fatty acid metabolism.
However, muscle also secretes cytokines and growth factors (collectively termed myokines) that …

Maintaining proper energy balance in mammals entails intimate crosstalk between various
tissues and organs. These inter-organ communications are mediated, to a great extent, by …

Tissue-tissue communication by endocrine factors is a vital mechanism for physiologic
homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort of …

An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …

The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …

Signaling pathways that promote adipose tissue thermogenesis are well characterized, but
the limiters of energy expenditure are largely unknown. Here, we show that ablation of the …

The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized
inbred strains of mice that can be used to analyze the genetic and environmental …

CTRP3 is a secreted plasma protein of the C1q family that helps regulate hepatic gluconeogenesis
and is downregulated in a diet-induced obese state. However, the role of CTRP3 in …

Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout
the central nervous system. Expression is particularly high around areas in contact with …