User profiles for Marcus O. Muench
 | Marcus O. Muench Ph.D.Senior Scientist, Vitalant Research Institute Verified email at vitalant.org Cited by 9155 |
Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
As the immune system develops, T cells are selected or regulated to become tolerant of self
antigens and reactive against foreign antigens. In mice, the induction of such tolerance is …
antigens and reactive against foreign antigens. In mice, the induction of such tolerance is …
Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac
…, JC Chang, AI Beyer, J Wang, MO Muench… - Genome …, 2014 - genome.cshlp.org
β-thalassemia, one of the most common genetic diseases worldwide, is caused by mutations
in the human hemoglobin beta (HBB) gene. Creation of human induced pluripotent stem …
in the human hemoglobin beta (HBB) gene. Creation of human induced pluripotent stem …
Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63
The human coronaviruses (CoVs) severe acute respiratory syndrome (SARS)-CoV and
NL63 employ angiotensin-converting enzyme 2 (ACE2) for cell entry. It was shown that …
NL63 employ angiotensin-converting enzyme 2 (ACE2) for cell entry. It was shown that …
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
Individuals homozygous for the CC chemokine receptor type 5 gene with 32-bp deletions (CCR5Δ32)
are resistant to HIV-1 infection. In this study, we generated induced pluripotent …
are resistant to HIV-1 infection. In this study, we generated induced pluripotent …
Whole-genome fingerprint of the DNA methylome during human B cell differentiation
…, D Alignani, B Paiva, G Caron, T Fest, MO Muench… - Nature …, 2015 - nature.com
We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation
program by whole-genome bisulfite sequencing and high-density microarrays. We …
program by whole-genome bisulfite sequencing and high-density microarrays. We …
Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro
…, S Wu, X Deng, MO Muench… - Blood, The Journal …, 2014 - ashpublications.org
Extracellular vesicles (EVs) are small, double membrane vesicles derived from leukocytes,
platelets, and cells of other tissues under physiological or pathological conditions. …
platelets, and cells of other tissues under physiological or pathological conditions. …
Identification of a common T/natural killer cell progenitor in human fetal thymus.
MJ Sanchez, MO Muench, MG Roncarolo… - The Journal of …, 1994 - rupress.org
The phenotypic similarities between natural killer (NK) and T cells have led to the hypothesis
that these distinctive lymphocyte subsets may be developmentally related and thus may …
that these distinctive lymphocyte subsets may be developmentally related and thus may …
Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia
…, Y Tan, AI Beyer, F Xie, MO Muench… - Proceedings of the …, 2016 - National Acad Sciences
Hereditary persistence of fetal hemoglobin (HPFH) is a condition in some individuals who
have a high level of fetal hemoglobin throughout life. Individuals with compound heterozygous …
have a high level of fetal hemoglobin throughout life. Individuals with compound heterozygous …
[HTML][HTML] A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease
The mosquito-borne alphavirus, chikungunya virus (CHIKV), has recently reemerged,
producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute …
producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute …
SOX2 regulates acinar cell development in the salivary gland
10.7554/eLife.26620.001 Acinar cells play an essential role in the secretory function of exocrine
organs. Despite this requirement, how acinar cells are generated during organogenesis …
organs. Despite this requirement, how acinar cells are generated during organogenesis …