Being a morning person is a behavioural indicator of a person’s underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we …

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Disrupted circadian rhythms and reduced sleep duration are associated with several human
diseases, particularly obesity and type 2 diabetes, but until recently, little was known about …

Objective To determine whether height and body mass index (BMI) have a causal role in
five measures of socioeconomic status. Design Mendelian randomisation study to test for …

Sleep is an essential human function but its regulation is poorly understood. Using accelerometer
data from 85,670 UK Biobank participants, we perform a genome-wide association …

Background: Previous studies have suggested that modern obesogenic environments
accentuate the genetic risk of obesity. However, these studies have proven controversial as to …

Background Depression is more common in obese than non-obese individuals, especially
in women, but the causal relationship between obesity and depression is complex and …

Recent genetic studies have identified some alleles that are associated with higher BMI but
lower risk of type 2 diabetes, hypertension, and heart disease. These “favorable adiposity” …

Genome-wide association studies of birth weight have focused on fetal genetics, whereas
relatively little is known about the role of maternal genetic variation. We aimed to identify …