Current research in drug discovery from medicinal plants involves a multifaceted approach
combining botanical, phytochemical, biological, and molecular techniques. Medicinal plant …

Organic compounds from terrestrial and marine organisms have extensive past and present
use in the treatment of many diseases and serve as compounds of interest both in their …

Despite rapid evolution in the area of microbial natural products chemistry, there is currently
no open access database containing all microbially produced natural product structures. …

The annotation of small molecules is one of the most challenging and important steps in
untargeted mass spectrometry analysis, as most of our biological interpretations rely on …

To the Editor—We introduce a webenabled mass spectrometry (MS) search engine, named
Mass Spectrometry Search Tool (MASST; https://masst. ucsd. edu). By enabling searches of …

Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody,
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …

With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of
postmenopausal estrogen receptor-positive breast cancer, researchers have also been …

Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp
of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal …

Tropical parasitic and infectious diseases, such as leishmaniasis, pose enormous global
health threats, but are largely neglected in commercial drug discovery programs. However, the …

Developments in computational omics technologies have provided new means to access the
hidden diversity of natural products, unearthing new potential for drug discovery. In parallel…