In mammals the stress-inducible expression of genes encoding heat shock proteins is under
the control of the heat shock transcription factor 1 (HSF1). Activation of HSF1 is a multistep …

Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress
while also mediating a cancer-specific transcriptional program. HSF1 is thought to be …

Transcription by RNA Polymerase II (Pol II) is initiated by the hierarchical assembly of the
pre-initiation complex onto promoter DNA. Decades of research have shown that the TATA-box …

The extracellular molecular chaperone heat shock protein 90 (eHSP90) stabilizes protease
client the matrix metalloproteinase 2 (MMP2), leading to tumor cell invasion. Although co-…

Maintenance of protein homeostasis, through inducible expression of molecular chaperones,
is essential for cell survival under protein-damaging conditions. The expression and DNA-…

A large number of transcription factors have been shown to bind and interact with mitotic
chromosomes, which may promote the efficient reactivation of transcriptional programs …

Mitosis involves intricate steps, such as DNA condensation, nuclear membrane disassembly,
and phosphorylation cascades that temporarily halt gene transcription. Despite this …

Defects in cellular protein homeostasis are associated with many severe and prevalent
pathological conditions such as neurodegenerative diseases, muscle dystrophies, and metabolic …

Organisms are constantly exposed to acute and chronic stress conditions, which challenge
the maintenance of protein homeostasis. Heat Shock Proteins (HSPs) function as molecular …

At the heart of the transcription process is the specific interaction between transcription factors
(TFs) and their target DNA sequences. Decades of molecular biology research have led to …