We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Cerebral Hemorrhages after t-PA in a Patient Treated with Lecanemab A patient with mild
cognitive impairment who was treated in the extension phase of a trial of lecanemab, an …

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC)
and Alzheimer’s disease neuropathologic change (ADNC) are each associated with …

An international consensus report in 2019 recommended a classification system for limbic-predominant
age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The …

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed
whole-genome sequencing in large cohorts of LBD cases and neurologically healthy …

Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for
Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites …

Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are early
events in Alzheimer’s disease (AD) that lead to cognitive deficits; however, the underlying …

Translating human genetic findings (genome-wide association studies [GWAS]) to pathobiology
and therapeutic discovery remains a major challenge for Alzheimer’s disease (AD). We …

A primary goal of research in cognitive impairment and dementia is to understand how
some individuals retain sufficient cognitive function for a fulfilling life while many others are …

The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic
innervation of the human cerebral cortex. They are involved in the cognitive processes of …