Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …

To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC),
we combined single-cell RNA sequencing with spatial transcriptomics and …

Noncoding variants of presumed regulatory function contribute to the heritability of
neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten …

Viral proteins localize within subcellular compartments to subvert host machinery and
promote pathogenesis. To study SARS-CoV-2 biology, we generated an atlas of 2422 human …

Network biology is useful for modeling complex biological phenomena; it has attracted
attention with the advent of novel graph-based machine learning methods. However, biological …

Epidermal homeostasis is governed by a balance between keratinocyte proliferation and
differentiation with contributions from cell–cell interactions, but conserved or divergent …

Gene expression is controlled by transcription factors (TFs) that bind cognate DNA motif
sequences in cis-regulatory elements (CREs). The combinations of DNA motifs acting within …

Glucose is a universal energy currency for living organisms, however, its non-energetic
functions in processes such as differentiation are undefined. In epidermis, differentiating cells …

Wnt signaling is one of the key oncogenic pathways in multiple cancers, and targeting this
pathway is an attractive therapeutic approach. However, therapeutic success has been limited …

The T-box family transcription factor gene TBX20 acts in a conserved regulatory network,
guiding heart formation and patterning in diverse species. Mouse Tbx20 is expressed in …