Microarray analysis reveals age‐related differences in gene expression during the development of osteoarthritis in mice
RF Loeser, AL Olex, MA McNulty… - Arthritis & …, 2012 - Wiley Online Library
Objective To better understand the contribution of age to the development of osteoarthritis (OA).
Methods Surgical destabilization of the medial meniscus (DMM) was used to model OA …
Methods Surgical destabilization of the medial meniscus (DMM) was used to model OA …
[HTML][HTML] Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis
RF Loeser, AL Olex, MA McNulty, CS Carlson… - PloS one, 2013 - journals.plos.org
Osteoarthritis (OA) is the most common form of arthritis and has multiple risk factors including
joint injury. The purpose of this study was to characterize the histologic development of OA …
joint injury. The purpose of this study was to characterize the histologic development of OA …
[HTML][HTML] Histopathology of naturally occurring and surgically induced osteoarthritis in mice
MA McNulty, RF Loeser, C Davey, MF Callahan… - Osteoarthritis and …, 2012 - Elsevier
OBJECTIVE: The morphology of lesions in mouse models of osteoarthritis (OA) has not been
comprehensively characterized, in part because current histological assessments of OA …
comprehensively characterized, in part because current histological assessments of OA …
A comprehensive histological assessment of osteoarthritis lesions in mice
MA McNulty, RF Loeser, C Davey, MF Callahan… - Cartilage, 2011 - journals.sagepub.com
Objective: Accurate histological assessment of osteoarthritis (OA) is critical in studies evaluating
the effects of interventions on disease severity. The purpose of the present study was to …
the effects of interventions on disease severity. The purpose of the present study was to …
Sclerostin antibody treatment improves implant fixation in a model of severe osteoporosis
AS Virdi, J Irish, K Sena, M Liu, HZ Ke, MA McNulty… - JBJS, 2015 - journals.lww.com
Background: The mechanical fixation of orthopaedic and dental implants is compromised by
diminished bone volume, such as with osteoporosis. Systemic administration of sclerostin …
diminished bone volume, such as with osteoporosis. Systemic administration of sclerostin …
Reduced osteoarthritis severity in aged mice with deletion of macrophage migration inhibitory factor
MA Rowe, LR Harper, MA McNulty… - Arthritis & …, 2017 - Wiley Online Library
Objective Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is
elevated in the serum and synovial fluid of patients with osteoarthritis (OA). This study was …
elevated in the serum and synovial fluid of patients with osteoarthritis (OA). This study was …
The glass ceiling thickens: the impact of COVID-19 on academic medicine faculty in the United States
RS Lufler, MA McNulty - Medical Education Online, 2022 - Taylor & Francis
The inequities faced by women in academic Medicine before the COVID-19 pandemic are
well established. However, there is little formal data regarding exactly how the pandemic has …
well established. However, there is little formal data regarding exactly how the pandemic has …
Sclerostin antibody increases bone volume and enhances implant fixation in a rat model
AS Virdi, M Liu, K Sena, J Maletich, M McNulty, HZ Ke… - JBJS, 2012 - journals.lww.com
Background: Previous studies have demonstrated that sclerostin blockade is anabolic for
bone. This study examined whether systemic administration of sclerostin antibody would …
bone. This study examined whether systemic administration of sclerostin antibody would …
[HTML][HTML] Loss of oncostatin M signaling in adipocytes induces insulin resistance and adipose tissue inflammation in vivo
Oncostatin M (OSM) is a multifunctional gp130 cytokine. Although OSM is produced in
adipose tissue, it is not produced by adipocytes. OSM expression is significantly induced in …
adipose tissue, it is not produced by adipocytes. OSM expression is significantly induced in …
[HTML][HTML] Novel lesions of bones and joints associated with chikungunya virus infection in two mouse models of disease: new insights into disease pathogenesis
BA Goupil, MA McNulty, MJ Martin, MK McCracken… - PloS one, 2016 - journals.plos.org
Chikungunya virus is an arbovirus spread predominantly by Aedes aegypti and Ae. albopictus
mosquitoes, and causes debilitating arthralgia and arthritis. While these are common …
mosquitoes, and causes debilitating arthralgia and arthritis. While these are common …