Severe sepsis remains a poorly understood systemic inflammatory condition with high
mortality rates and limited therapeutic options in addition to organ support measures. Here we …

The spatial separation of mRNA synthesis from translation, while providing eukaryotes with
the possibility to achieve higher complexity through a more elaborate regulation of gene …

The premessenger RNA of the majority of human genes can generate various transcripts
through alternative splicing, and different tissues or disease states show specific patterns of …

U2AF 65 is an essential splicing factor that promotes binding of U2 small nuclear (sn)RNP
at the pre-mRNA branchpoint. Here we describe a novel monoclonal antibody that reacts …

Repetitive DNA is a major organizational component of eukaryotic genomes, being
intrinsically related with their architecture and evolution. Tandemly repeated satellite DNAs (satDNAs…

Germinal centers (GCs) are anatomic structures where B cells undergo affinity maturation,
leading to production of high-affinity antibodies. The balance between T follicular helper (T FH …

Background Pre-mRNA splicing is an essential step in gene expression that occurs co-transcriptionally
in the cell nucleus, involving a large number of RNA binding protein splicing …

Fasciola hepatica, a global worm parasite of humans and their livestock, regulates host
innate immune responses within hours of infection. Host macrophages, essential to the first-line …

Non-alcoholic fatty liver disease (NAFLD) pathogenesis associates with intramyocellular lipid
deposition and mitochondrial dysfunction. microRNAs (miRs), including pro-apoptotic miR-…

microRNAs are post-transcriptional regulators of gene expression that have been shown to
be central players in the establishment of cellular programs, often acting as switches that …