Subcutaneous delivery of monoclonal antibodies: how do we get there?

M Viola, J Sequeira, R Seiça, F Veiga, J Serra… - Journal of controlled …, 2018 - Elsevier
The convenience of subcutaneous (SC) administration and the increasing interest in
monoclonal antibody (mAb)-based therapies for chronic diseases, hint their potential for SC …

[HTML][HTML] The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis

…, E van der Worp, M Wesseling, M Viola… - Heart Failure …, 2020 - Springer
The transverse aortic constriction (TAC) model is frequently used to study adverse cardiac
remodeling upon pressure overload. We set out to define the most important characteristics …

[HTML][HTML] Targeting inflammation after myocardial infarction: a therapeutic opportunity for extracellular vesicles?

M Viola, SCA de Jager, JPG Sluijter - International Journal of Molecular …, 2021 - mdpi.com
After myocardial infarction (MI), a strong inflammatory response takes place in the heart to
remove the dead tissue resulting from ischemic injury. A growing body of evidence suggests …

[HTML][HTML] Re-annotation of 191 developmental and epileptic encephalopathy-associated genes unmasks de novo variants in SCN1A

…, D Pervouchine, S Fitzgerald, M Viola… - npj Genomic …, 2019 - nature.com
The developmental and epileptic encephalopathies (DEE) are a group of rare, severe
neurodevelopmental disorders, where even the most thorough sequencing studies leave 60–65% …

Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes

M Viola, MP Bebelman, RGC Maas, FJ Verweij… - bioRxiv, 2024 - biorxiv.org
Extracellular vesicles (EVs) have emerged as important mediators of intercellular
communication in the heart under homeostatic and pathological conditions, such as myocardial …

Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition

…, B Snieder, E Thanou, CJM Langedijk, M Viola… - bioRxiv, 2023 - biorxiv.org
Dysregulated extracellular vesicle (EV) release has been implicated in various pathologies,
including cancer, neurodegenerative disease and osteoarthritis. Despite clear therapeutic …

Systematic re-annotation of 191 genes associated with early-onset epilepsy unmasks de novo variants linked to Dravet syndrome in novel SCN1A exons

…, D Pervouchine, S Fitzgerald, M Viola… - bioRxiv, 2019 - biorxiv.org
The early infantile epileptic encephalopathies (EIEE) are a group of rare, severe
neurodevelopmental disorders, where even the most thorough sequencing studies leave 60-65% of …

Resveratrol: do laboratório à clínica

AMC Viola - 2016 - estudogeral.uc.pt
O interesse terapêutico do resveratrol tem aumentado nos últimos anos. Apesar do
ceticismo em relação à sua biodisponibilidade, evidências crescentes in vivo indicam que o …

[PDF][PDF] Relatório de estágio curricular em farmácia comunitária

AMC Viola - 2016 - estudogeral.uc.pt
Este relatório insere-se no âmbito do Estágio Curricular em farmácia comunitária do
Mestrado Integrado em Ciências Farmacêuticas (MICF) da Faculdade de Farmácia da …

É um ser vivo: substituição, adaptação e padronização de instrumentos musicais entre África, Europa e Brasil

N Graeff - Per Musi, 2023 - periodicos.ufmg.br
… Pedi para fotografar os dois instrumentos, enquanto ele me contava como diversas pessoas
o abordaram para comprar, pegar emprestado, levar a viola Margarida para o museu da …