Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the
mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is …

Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as
primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores pose …

The antifungal drug 5-flucytosine (5FC), a derivative of the nucleobase cytosine, is licensed
for the treatment of fungal diseases; however, it is rarely used as a monotherapeutic to treat …

Intracellular occupancy of the respiratory epithelium is a useful pathogenic strategy facilitating
microbial replication and evasion of professional phagocytes or circulating antimicrobial …

The origin of isolates routinely used by the community of Aspergillus fumigatus researchers
is periodically a matter of intense discussion at our centre, as the construction of recombinant …

TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing
CD226 co-stimulation through interactions in cis or through competition of shared ligands. …

Aspergillus fumigatus spores initiate more than 3,000,000 chronic and 300,000 invasive
diseases annually, worldwide. Depending on the immune status of the host, inhalation of these …

… In agreement with data previously published by Bertuzzi et al. (3), both live spores and CF 48
of … Uju Joy Okaa and Margherita Bertuzzi contributed equally to this article. The order of first …

The A spergillus nidulans PacC transcription factor mediates gene regulation in response to
alkaline ambient pH which, signalled by the P al pathway, results in the processing of PacC …

Aspergillus fumigatus is an inhaled fungal pathogen of human lungs, the developmental
growth of which is reliant upon Ca 2+ -mediated signalling. Ca 2+ signalling has regulatory …