The performance and safety of current antineoplastic agents, particularly water-insoluble
drugs, are still far from satisfactory. For example, the currently widely used Cremophor EL®-…

… Address correspondence and reprint requests to Margit M. Janát-Amsbury, MD, PhD, Division
of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Utah, …

Estrogen receptor alpha (ER) is a key oncogene in endometrial cancer. This study uncovers
ETV4 as an important factor in controlling the activity of ER and the growth of endometrial …

Endometrial hyperplasia ( EH ) is a condition originating from uterine endometrial glands
undergoing disordered proliferation including the risk to progress to endometrial …

The major drawback hampering siRNA therapies from being more widely accepted in clinical
practice is its insufficient accumulation at the target site mainly due to poor cellular uptake …

Purpose The safe and functional delivery of progesterone through the vaginal route remains
an unmet clinical need. The purpose of this work is to prepare a new progesterone (P4) gel …

In this study, a new thermo-sensitive polymer, glycol chitin, was synthesized by controlled N-acetylation
of glycol chitosan and evaluated as a thermogelling system. The physico-…

Vaginal drug delivery represents an attractive strategy for local and systemic delivery of drugs
otherwise poorly absorbed after oral administration. The rather dense vascular network, …

Checkpoint blockade immunotherapies harness the host's own immune system to fight
cancer, but only work against tumors infiltrated by swarms of preexisting T cells. Unfortunately, …

Purpose: Safety and efficacy of acapatamab, a prostate-specific membrane antigen (PSMA)
x CD3 bispecific T-cell engager were evaluated in a first-in-human study in metastatic …