Background Brain inflammation has been recognized as a complex phenomenon with
numerous related aspects. In addition to the very well-described neurodegenerative effect of …

Damage to the integrity of the vessel wall leads to exposure of the subendothelial extracellular
matrix (ECM), triggering platelet activation and aggregation. This process is essential for …

Platelet aggregation is essential for hemostasis but can also cause myocardial infarction
and stroke. A key but poorly understood step in platelet activation is the shift of the principal …

Alzheimer’s disease (AD) is characterized by neurotoxic amyloid-ß plaque formation in
brain parenchyma and cerebral blood vessels known as cerebral amyloid angiopathy (CAA). …

Platelets are activated on increase of cytosolic Ca 2+ activity ([Ca 2+ ] i ), accomplished by
store-operated Ca 2+ entry (SOCE) involving the pore-forming ion channel subunit Orai1. …

Platelet activation at sites of vascular injury is triggered through different signaling pathways
leading to activation of phospholipase (PL) Cβ or PLCγ2. Active PLCs trigger Ca 2+ …

Platelet activation at sites of vascular injury is crucial for hemostasis, but it may also cause
myocardial infarction or stroke. Cytoskeletal reorganization is essential for platelet activation …

Cerebral amyloid angiopathy (CAA) is a vascular dysfunction disorder characterized by
deposits of amyloid-β (Aβ) in the walls of cerebral vessels. CAA and Aβ deposition in the brain …

Thrombotic, vascular, and bleeding complications are the most common causes of morbidity
and mortality in the Philadelphia chromosome–negative myeloproliferative neoplasms (…

Red blood cells (RBCs) influence rheology, and release ADP, ATP, and nitric oxide,
suggesting a role for RBCs in hemostasis and thrombosis. Here, we provide evidence for a …