Deposition of α-synuclein into Lewy bodies and Lewy neurites is the hallmark of Parkinson’s
disease (PD). It is hypothesized that α-synuclein pathology spreads by a “prion-like” …

The extraordinary diversity of the human immunodeficiency virus type 1 (HIV-1) envelope (Env)
glycoprotein poses a major challenge for the development of an HIV-1 vaccine. One …

Misfolding and aggregation of tau protein are closely associated with the onset and progression
of Alzheimer’s Disease (AD). By interrogating IgG + memory B cells from asymptomatic …

PEGylation has been suggested to improve the stability of insulin, but evidence for that is
scarce. Here, we compared the forced aggregation behavior of insulin and mono-PEGylated …

Misfolding and aggregation of tau protein are closely associated with the onset and progression
of Alzheimer’s Disease (AD). By interrogating IgG + memory B cells from asymptomatic …

… The authors would like to thank Hector Quirante for the expression and purification of
huTau441, Hanna Inganäs and Margot van Winsen for excellent technical support and Martin …

… Perdok and Sjoerd Renger for protein purification and Fab generation and Hanna Inganäs
and Margot van Winsen for protein analysis and SEC-MALS based binding measurements. …

Aggregation of tau protein and spreading of tau aggregates are pivotal pathological
processes in a range of neurological disorders. Accumulating evidence suggests that …

… My big thanks go to Margot van Winsen who patiently guided me through the practical part
… example hydrogen bonding, electrostatic interactions or van der Waals forces. The affinity of …

Several reports have described the presence of antibodies against Alzheimer’s disease-associated
hyperphosphorylated forms of tau in serum of healthy individuals. To characterize …