Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer
therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes …

Epigenetic silencing is mediated by families of factors that place, remove, read, and transmit
repressive histone and DNA methylation marks on chromatin. How the roles for these …

Anti-Müllerian hormone (AMH) and its type II receptor AMHR2, both previously thought to
primarily function in gonadal tissue, were unexpectedly identified as potent regulators of …

CDK4/6 targeting is a promising therapeutic strategy under development for various tumor
types. In this study, we used computational methods and The Cancer Genome Atlas dataset …

Cas-family proteins have been implicated as signaling intermediaries in diverse processes
including cellular attachment, motility, growth factor response, apoptosis and oncogenic …

Targeted therapies have been used to combat many tumor types; however, few have
effectively improved the overall survival in women with epithelial ovarian cancer, begging for a …

HEF1 (human enhancer of filamentation 1) is a member of a docking protein family that
includes p130 Cas and Efs. Through assembly of multiple protein interactions at focal adhesion …

KIR2DL4 (CD158d) is a distinct member of the killer cell Ig-like receptor (KIR) family in
human NK cells that can induce cytokine production and cytolytic activity in resting NK cells. …

Glutathione-S-transferase (GST) fusion proteins have had a wide range of applications
since their introduction as tools for synthesis of recombinant proteins in bacteria. GST was …

Head and neck squamous cell carcinomas (HNSCC) affect more than 800,000 people
annually worldwide, causing over 15,000 deaths in the US. Among HNSCC cancers, human …