Low bone mineral density (BMD) is used as a parameter of osteoporosis. Genome-wide
association studies of BMD have hitherto focused on BMD as a quantitative trait, yielding …

Sequence polymorphisms linked to human diseases and phenotypes in genome-wide
association studies often affect noncoding regions. A SNP within an intron of the gene encoding …

Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte
development and an important oncogene in melanoma. MITF heterodimeric assembly with …

Background: The use of proton-pump inhibitors (PPIs) has grown worldwide, and there are
concerns about increased unsubstantiated long-term use. The aim of the study was to …

… In light of the recent identification of the vacuolar H + -ATPase as another Rag-interacting
component, we propose a model in which PATs function as part of an AA-sensing engine that …

The MITF transcription factor is a master regulator of melanocyte development and a critical
factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate …

The basic-helix–loop–helix-leucine zipper (bHLHZip) protein MITF (microphthalmia-associated
transcription factor) is a master regulator of melanocyte development. Mutations in the …

Autophagy is a housekeeping mechanism tasked with eliminating misfolded proteins and
damaged organelles to maintain cellular homeostasis. Autophagy deficiency results in …

mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor,
nutrient and oxygen levels modulate intracellular events critical for the viability and growth of …

Maedi-visna virus (MVV) is a lentivirus of sheep causing chronic inflammatory disease of the
lungs (maedi) and the nervous system (visna). We have previously shown that a duplicated …