Gangliosides are sialic acid-containing glycosphingolipids that are present on all mammalian
plasma membranes where they participate in recognition and signaling activities. We have …

Sphingosine-1-phosphate (S1P) elicits diverse cellular responses through a family of G-protein-coupled
receptors. We have shown previously that genetic disruption of the S1P 1 …

The sphingosine 1-phosphate receptor 1 (S1P 1 ) is abundant in endothelial cells, where it
regulates vascular development and microvascular barrier function. In investigating the role …

The S1P 2 receptor is a member of a family of G protein-coupled receptors that bind the
extracellular sphingolipid metabolite sphingosine 1-phosphate with high affinity. The receptor is …

Gangliosides are a family of glycosphingolipids that contain sialic acid. Although they are
abundant on neuronal cell membranes, their precise functions and importance in the central …

Lipid mediators influence immunity in myriad ways. For example, circulating sphingosine-1-phosphate
(S1P) is a key regulator of lymphocyte egress 1 , 2 . Although the majority of …

Very long chain fatty acids (VLCFA), either free or as components of glycerolipids and
sphingolipids, are present in many organs. Elongation of very long chain fatty acids-4 (ELOVL4) …

Gaucher disease, the most common lysosomal storage disease, is caused by a deficiency
of glucocerebrosidase resulting in the impairment of glucosylceramide degradation. The …

Complex sphingolipids are abundant as eukaryotic cell membrane components, whereas
their metabolites, in particular ceramide, sphingosine, and sphingosine 1-phosphate, are …

Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular
protective pathways may provide therapeutic targets for neurological disorders. S1P (…