Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…

Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …

Smoking is a common risk factor for many diseases 1 . We conducted genome-wide
association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well …

Using principal component (PC) analysis, we studied the genetic constitution of 3,112
individuals from Europe as portrayed by more than 270,000 single nucleotide polymorphisms (…

Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have
identified several genetic loci associated with typical AF. We sought to identify common genetic …

We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) …

Elevated resting heart rate is associated with greater risk of cardiovascular disease and
mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 …

Rare copy-number variants (rCNVs) include deletions and duplications that occur infrequently
in the global human population and can confer substantial risk for disease. In this study, …