User profiles for Maria E. Cicardi
Maria Elena CicardiThomas Jefferson University Verified email at jefferson.edu Cited by 1350 |
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons
counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be …
counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be …
[HTML][HTML] NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
A G4C2 hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic
cause of ALS and FTLD (C9-ALS/FTLD) with cytoplasmic TDP-43 inclusions observed in …
cause of ALS and FTLD (C9-ALS/FTLD) with cytoplasmic TDP-43 inclusions observed in …
[HTML][HTML] Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells
R Cristofani, M Montagnani Marelli, ME Cicardi… - Cell Death & …, 2018 - nature.com
Prostate cancer (PC) is one of the leading causes of death in males. Available treatments
often lead to the appearance of chemoresistant foci and metastases, with mechanisms still …
often lead to the appearance of chemoresistant foci and metastases, with mechanisms still …
[PDF][PDF] Isogenic FUS-eGFP iPSC reporter lines enable quantification of FUS stress granule pathology that is rescued by drugs inducing autophagy
…, C Moebius, E Koerner, L Reinhardt, ME Cicardi… - Stem cell reports, 2018 - cell.com
Perturbations in stress granule (SG) dynamics may be at the core of amyotrophic lateral
sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in …
sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in …
The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity
V Crippa, ME Cicardi, N Ramesh… - Human Molecular …, 2016 - academic.oup.com
Aggregation of TAR-DNA-binding protein 43 (TDP-43) and of its fragments TDP-25 and TDP-35
occurs in amyotrophic lateral sclerosis (ALS). TDP-25 and TDP-35 act as seeds for TDP-…
occurs in amyotrophic lateral sclerosis (ALS). TDP-25 and TDP-35 act as seeds for TDP-…
[HTML][HTML] The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases
…, G Vezzoli, P Rusmini, M Galbiati, ME Cicardi… - Cell Stress and …, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two
neurodegenerative diseases in which similar pathogenic mechanisms are involved. Both diseases …
neurodegenerative diseases in which similar pathogenic mechanisms are involved. Both diseases …
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis
ME Cicardi, L Marrone, M Azzouz, D Trotti - The EMBO journal, 2021 - embopress.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact causative
mechanisms are still under intense investigation. Several lines of evidence suggest that …
mechanisms are still under intense investigation. Several lines of evidence suggest that …
Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases
Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral
sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar …
sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar …
[HTML][HTML] Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases
…, R Cristofani, P Rusmini, ME Cicardi, E Messi… - Scientific reports, 2016 - nature.com
Neurodegenerative diseases (NDs) are often associated with the presence of misfolded
protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and muscle …
protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and muscle …
[HTML][HTML] Tdp-25 routing to autophagy and proteasome ameliorates its aggregation in amyotrophic lateral sclerosis target cells
ME Cicardi, R Cristofani, P Rusmini, M Meroni… - Scientific reports, 2018 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that primarily affects
motoneurons, while non-neuronal cells may contribute to disease onset and progression. …
motoneurons, while non-neuronal cells may contribute to disease onset and progression. …