User profiles for Maria E. Cicardi

Maria Elena Cicardi

Thomas Jefferson University
Verified email at jefferson.edu
Cited by 1350

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

…, K Cortese, V Crippa, R Cristofani, ME Cicardi… - Autophagy, 2019 - Taylor & Francis
Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons
counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be …

[HTML][HTML] NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility

…, EL Daley, JA Ortega, ME Cicardi, E Kiskinis… - Nature …, 2022 - nature.com
A G4C2 hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic
cause of ALS and FTLD (C9-ALS/FTLD) with cytoplasmic TDP-43 inclusions observed in …

[HTML][HTML] Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells

R Cristofani, M Montagnani Marelli, ME Cicardi… - Cell Death & …, 2018 - nature.com
Prostate cancer (PC) is one of the leading causes of death in males. Available treatments
often lead to the appearance of chemoresistant foci and metastases, with mechanisms still …

[PDF][PDF] Isogenic FUS-eGFP iPSC reporter lines enable quantification of FUS stress granule pathology that is rescued by drugs inducing autophagy

…, C Moebius, E Koerner, L Reinhardt, ME Cicardi… - Stem cell reports, 2018 - cell.com
Perturbations in stress granule (SG) dynamics may be at the core of amyotrophic lateral
sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in …

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

V Crippa, ME Cicardi, N Ramesh… - Human Molecular …, 2016 - academic.oup.com
Aggregation of TAR-DNA-binding protein 43 (TDP-43) and of its fragments TDP-25 and TDP-35
occurs in amyotrophic lateral sclerosis (ALS). TDP-25 and TDP-35 act as seeds for TDP-…

[HTML][HTML] The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases

…, G Vezzoli, P Rusmini, M Galbiati, ME Cicardi… - Cell Stress and …, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two
neurodegenerative diseases in which similar pathogenic mechanisms are involved. Both diseases …

Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis

ME Cicardi, L Marrone, M Azzouz, D Trotti - The EMBO journal, 2021 - embopress.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact causative
mechanisms are still under intense investigation. Several lines of evidence suggest that …

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases

…, ME Cicardi, M Meroni, NV Licata, G Sala, E Giorgetti… - Autophagy, 2017 - Taylor & Francis
Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral
sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar …

[HTML][HTML] Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

…, R Cristofani, P Rusmini, ME Cicardi, E Messi… - Scientific reports, 2016 - nature.com
Neurodegenerative diseases (NDs) are often associated with the presence of misfolded
protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and muscle …

[HTML][HTML] Tdp-25 routing to autophagy and proteasome ameliorates its aggregation in amyotrophic lateral sclerosis target cells

ME Cicardi, R Cristofani, P Rusmini, M Meroni… - Scientific reports, 2018 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that primarily affects
motoneurons, while non-neuronal cells may contribute to disease onset and progression. …