A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.

JE Segall, A Kuspa, G Shaulsky, M Ecke… - The Journal of cell …, 1995 - rupress.org
Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate
morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of …

Protection against osmotic stress by cGMP-mediated myosin phosphorylation

H Kuwayama, M Ecke, G Gerisch, PJM Van Haastert - Science, 1996 - science.org
Conventional myosin functions universally as a generator of motive force in eukaryotic cells.
Analysis of mutants of the microorganism Dictyostelium discoideum revealed that myosin …

Three-dimensional Patterns and Redistribution of Myosin II and Actin in Mitotic Dictyostelium Cells

R Neujahr, C Heizer, R Albrecht, M Ecke… - The Journal of cell …, 1997 - rupress.org
Myosin II is not essential for cytokinesis in cells of Dictyostelium discoideum that are anchored
on a substrate (Neujahr, R., C. Heizer, and G. Gerisch. 1997. J. Cell Sci. 110:123–137), in …

Evolved, selective erasers of distinct lysine acylations

M Spinck, P Neumann‐Staubitz, M Ecke… - Angewandte Chemie …, 2020 - Wiley Online Library
Lysine acylations, a family of diverse protein modifications varying in acyl‐group length, charge,
and saturation, are linked to many important physiological processes. Only a small set of …

Stage-specific tyrosine phosphorylation of actin in Dictyostelium discoideum cells

A Schweiger, O Mihalache, M Ecke… - Journal of Cell …, 1992 - journals.biologists.com
A 45 kDa protein in Dictyostelium discoideum cells that was recognized by a
phosphotyrosine-specific antibody was identified by its binding activity to DNase I and its 2D-electrophoretic …

Highly sensitive lysine deacetylase assay based on acetylated firefly luciferase

M Spinck, M Ecke, S Sievers, H Neumann - Biochemistry, 2018 - ACS Publications
Lysine deacetylases (KDACs) play important roles in many physiological processes and are
implicated in many human diseases. Hence, the search for modulators of KDACs is very …

Evolvierte, selektive Eraser für spezifische Lysinacylierungen

M Spinck, P Neumann‐Staubitz, M Ecke… - Angewandte …, 2020 - Wiley Online Library
Lysinacylierungen treten in vielen wichtigen physiologischen Prozessen auf. Nur eine
kleine Anzahl Substrat‐promisker Lysin‐Acetyltransferasen und ‐Deacetylasen (KDACs) …

[HTML][HTML] Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK

…, BM Wiedemann, MP Müller, J Hardick, M Ecke… - Plos one, 2017 - journals.plos.org
In protein kinase research, identifying and addressing small molecule binding sites other than
the highly conserved ATP-pocket are of intense interest because this line of investigation …

Combination of different techniques in cryo-electron tomography with a Volta phase plate

M Khoshouei, G Gerisch, M Ecke, J Ortiz… - Microscopy and …, 2015 - cambridge.org
Due to the sensitivity of the biological samples to beam irradiation resulting from induced
changes to their structure, the limited allowed dose to frozen-hydrated biological specimens …

A directed evolution system for lysine deacetylases

M Spinck, M Ecke, D Schiller, H Neumann - … Complexes: Methods and …, 2021 - Springer
Lysine acetylation is a ubiquitous modification permeating the proteomes of organisms from
all domains of life. Lysine deacetylases (KDACs) reverse this modification by following two …