Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
…, C González-Villalpando, ME González-Villalpando… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
…, NP Burtt, CA Aguilar-Salinas, C González-Villalpando… - Nature, 2014 - escholarship.org
Performing genetic studies in multiple human populations can identify disease risk alleles
that are common in one population but rare in others, with the potential to illuminate …
that are common in one population but rare in others, with the potential to illuminate …
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population
…, X Soberón, ME González-Villalpando, E Henderson… - Jama, 2014 - jamanetwork.com
Importance Latino populations have one of the highest prevalences of type 2 diabetes worldwide.
Objectives To investigate the association between rare protein-coding genetic variants …
Objectives To investigate the association between rare protein-coding genetic variants …
[HTML][HTML] Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys
…, JP González-Rivas, C González-Villalpando… - The Lancet Global …, 2020 - thelancet.com
Background Describing the prevalence and trends of cardiometabolic risk factors that are
associated with non-communicable diseases (NCDs) is crucial for monitoring progress, …
associated with non-communicable diseases (NCDs) is crucial for monitoring progress, …
[HTML][HTML] Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms
…, C González-Villalpando, ME González-Villalpando… - Cell, 2017 - cell.com
Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European
descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the …
descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the …
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
…, P Fontanillas, T Green, E Banks… - Proceedings of the …, 2014 - National Acad Sciences
Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional
regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione …
regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione …
[PDF][PDF] Incidence of type 2 diabetes in Mexico: results of the Mexico City Diabetes Study after 18 years of follow-up
C González-Villalpando… - salud pública de …, 2014 - SciELO Public Health
Objective. To estimate the incidence of type 2 diabetes (T2D) in Mexican population. Materials
and methods. Population based prospective study. At baseline (1990), the population at …
and methods. Population based prospective study. At baseline (1990), the population at …
A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes
…, C Contreras-Cubas, ME González-Villalpando… - Diabetes, 2017 - Am Diabetes Assoc
Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the
health care system continue to rise. To identify common or rare genetic variation with potential …
health care system continue to rise. To identify common or rare genetic variation with potential …
[PDF][PDF] The status of diabetes care in Mexican population: Are we making a difference? Results of the National Health and Nutrition Survey 2006
C González-Villalpando… - salud pública de …, 2010 - SciELO Public Health
OBJECTIVE: Examine clinical indicators to evaluate diabetes care in Mexico. MATERIAL
AND METHODS: Diabetics (self reported, with therapy) were examined with standardized …
AND METHODS: Diabetics (self reported, with therapy) were examined with standardized …
Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
…, C González-Villalpando, ME González-Villalpando… - MedRxiv, 2020 - medrxiv.org
We assembled an ancestrally diverse collection of genome-wide association studies of type
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …