8-Oxoguanine, a common mutagenic DNA lesion, generates G:C>T:A transversions via
mispairing with adenine during DNA replication. When operating normally, the MUTYH DNA …

Background: We explored the expression of Fatty Acid Synthase (FAS) in lung carcinomas
and its association with clinico-pathological features and prognosis. FAS is a recently …

These findings demonstrate the feasibility of an “off-the-shelf” vaccine for treatment and
prevention of tumors harboring frameshift mutations and neoantigenic peptides as a result of …

Multiple primary malignant neoplasms (MPMN) are not uncommon, however, finding more
than three primary malignancies in one individual is unusual. Surviving five malignancies is …

Background & Aims About 15% of intrahepatic cholangiocarcinomas (iCCAs) express
fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs), usually alongside mutational …

Background Human Leukocyte Antigen (HLA)-E is a non-classical class I HLA molecule that
can be stabilized by ligands donated by other classical (HLA-A, -B, -C) and non-classical (…

Morphologic examinations of mammary neoplasias arising in BALB/c (H-2d) mice carrying
the activated rat HER-2/neu oncogene (BALB-NeuT), and in FVB (H-2q) mice bearing the wild…

Background Approximately 20–50% of patients presenting with localized colorectal cancer
progress to stage IV metastatic disease (mCRC) following initial treatment and this is a major …

EphB2 and EphA2 control stemness and differentiation in the intestinal mucosa, but the way
they cooperate with the complex mechanisms underlying tumor heterogeneity and how they …

Background The role of Mandard's tumor regression grade (TRG) classification is still
controversial in defining the prognostic role of patients who have undergone neoadjuvant …