Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component
of a wide range of cellular and gene therapies. Recent efforts have achieved > 200‐fold …

Hematopoietic stem and progenitor cells (HSPCs) in the fetus and adult possess distinct
molecular landscapes that regulate cell fate and change their susceptibility to initiation and …

Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a
dismal prognosis. Here, we present a functional and proteomic characterization of in utero-…

The process of hematopoiesis is subject to substantial ontogenic remodeling that is accompanied
by alterations in cellular fate during both development and disease. We combine state-…

The YPEL family genes are highly conserved across a diverse range of eukaryotic organisms
and thus potentially involved in essential cellular processes. Ypel4, one of five YPEL family …

One of the most challenging aspects of stem cell research is the reliance on retrospective
assays for ascribing function. This is especially problematic for hematopoietic stem cell (HSC) …

Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary
genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass …

Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development
and homeostasis of the blood system. Self-renewal expansion divisions, which create two …

The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs)
remain incompletely understood. Here, we targeted global shRNA libraries to primary …

Fetal and adult hematopoiesis are regulated by largely distinct sets of cell-intrinsic gene
regulatory networks as well as extracellular cues in their respective microenvironment. These …