Deep generative neural networks have been used increasingly in computational chemistry
for de novo design of molecules with desired properties. Many deep learning approaches …

Introduction PX-478 is a potent small-molecule inhibitor of hypoxia-inducible factor 1α (HIF-1α).
In prior preclinical studies, it had antitumor activity against various solid tumors in …

Deep learning models have demonstrated outstanding results in many data-rich areas of
research, such as computer vision and natural language processing. Currently, there is a rise …

Purpose: Ras/Raf/mitogen-activated protein–extracellular signal-regulated kinase (ERK)
kinase (MEK)/ERK signaling is critical for tumor cell proliferation and survival. Selumetinib is a …

The data-driven design of protein sequences with desired function is challenged by the
absence of good theoretical models for the sequence-function mapping and the vast size of …

Deep generative neural networks have been used increasingly in computational chemistry
for de novo design of molecules with desired properties. Many deep learning approaches …

This thesis describes novel deep generative neural networks and their applications for the
de novo design of molecules with optimized properties. It discusses the background and …

Introduction: Multiple studies demonstrate that EGFR signaling confers a survival advantage
under hypoxic conditions by inducing VEGF expression through HIF-1α dependent and …

In my view, the main goal of a true and honest musician is to try to understand the ways in
which the composer expresses himself, and the underneath idea of his musical piece; and …

2495 Introduction: Small cell lung cancer (SCLC) has a dismal prognosis even after aggressive
conventional therapy. We have developed two distinct orthotopic models of human SCLC…