Altered metabolism is associated with many human diseases. Human genome-scale
metabolic models (GEMs) were reconstructed within systems biology to study the biochemistry …

Eukaryotic organisms play an important role in industrial biotechnology, from the production
of fuels and commodity chemicals to therapeutic proteins. To optimize these industrial …

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact
impact of specific metabolic changes on cancer progression is poorly understood. Here, we …

In this paper we consider, from the numerical point of view, a thermoelastic diffusion porous
problem. This is written as a coupled system of two hyperbolic equations, for the …

In this paper, we study, from a numerical point of view, an osseointegrated model depending
on the density of the osteogenic cells and osteoblasts and one generic growth factor. The …

Devising genetic interventions for desired cellular phenotypes remains challenging regarding
time and resources. Kinetic models can accelerate this task by simulating metabolic …

Motivation Large-scale kinetic models are an invaluable tool to understand the dynamic and
adaptive responses of biological systems. The development and application of these …

In this paper, we analyse a model involving a strain gradient thermoelastic rod with voids.
Existence and uniqueness, as well as an energy decay property, are proved by means of the …

In this paper we analyze an homogeneous and isotropic mixture of viscoelastic solids. We
propose conditions to guarantee the coercivity of the internal energy and also of the …

In this paper, a porous thermoelastic problem is numerically considered. The variational
formulation is written as a coupled system of two hyperbolic equations for the displacement and …