Intraneuronal accumulation of amyloid-β (Aβ) peptides represent an early pathological
feature in Alzheimer’s disease. We have therefore utilized flow cytometry and confocal …

Cholera toxin (CT) enters host intestinal epithelia cells, and its retrograde transport to the
cytosol results in the massive loss of fluids and electrolytes associated with severe dehydration. …

Copper (Cu) ions are cofactors in many essential enzymes. As free Cu ions are toxic, most
organisms have highly specialized Cu transport systems involving dedicated proteins. The …

Normal physiology relies on the precise coordination of intracellular signaling pathways that
respond to nutrient availability to balance cell growth and cell death. The canonical mitogen-…

The anaphase-promoting complex (APC) is involved in several processes in the cell cycle,
most prominently it facilitates the separation of the sister chromatids during mitosis, before …

Peptide AF-16, which includes the active site of Antisecretory Factor protein, has antisecretory
and anti-inflammatory properties, making it a potent drug candidate for treatment of …

Normal physiology relies on the precise coordination of intracellular signal transduction
pathways that respond to nutrient availability to balance cell growth and cell death. We recently …

Abstract Knowledge about mechanisms behind interactions of molecules with biomembranes
and cellular uptake is very important for understanding biological processes and for drug …

Copper (Cu) ions are cofactors in many essential enzymes. As free Cu ions are toxic, most
organisms have highly specialized Cu transport systems involving dedicated proteins. The …

Strand exchange between double-and single-stranded DNA is similar in all cell-based
organisms, where it plays a key role in both DNA repair and genetic diversity. In life, this reaction …