The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …

Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …

Mutations in LRRK2 and GBA1 are common genetic risk factors for Parkinson’s disease (PD)
and major efforts are underway to develop new therapeutics that target LRRK2 or …

Recently identified Parkinson’s disease (PD) genes involved in synaptic vesicle endocytosis,
such as DNAJC6 (auxilin), have further implicated synaptic dysfunction in PD pathogenesis…

Aims: Expression of the HER2 oncogene in breast cancer is associated with resistance to
treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether …

Aims: MiR126 was found to be frequently lost in many types of cancer, including malignant
mesothelioma (MM), which represents one of the most challenging neoplastic diseases. In …

Dendritic spines represent the major site of neuronal activity in the brain; they serve as the
receiving point for neurotransmitters and undergo rapid activity-dependent morphological …

Lysosomes are acidic, membrane-bound organelles that serve as the primary catabolic
compartment of the cell. They are crucial to a variety of cellular processes from nutrient storage …

Mobile genetic elements, elements that can move horizontally between genomes, have
profound effects on their host's fitness. The phage-inducible chromosomal island-like element (…

Mutations in GBA1, which encode for the protein glucocerebrosidase (GCase), are the most
common genetic risk factor for Parkinson's disease and dementia with Lewy bodies. In …