Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

The genetic architecture of human reproductive behavior—age at first birth (AFB) and number
of children ever born (NEB)—has a strong relationship with fitness, human development, …

Refractive errors, including myopia, are the most frequent eye disorders worldwide and an
increasingly common cause of blindness. This genome-wide association meta-analysis in …

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly
understood mechanisms. We performed a trans-ancestry genome-wide association study …

Homozygosity has long been associated with rare, often devastating, Mendelian disorders 1,
and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness 2. …

Age at first sexual intercourse and age at first birth have implications for health and
evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = …

Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we …

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are
influenced by smoking, but it is unknown whether genetic associations with lipids may be …